Scientific Studies

Unlike many other food supplements, Bimuno® is underpinned by a large and growing body of published scientific evidence.


Modulation of the faecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers.


Background: Aging is associated with reduced numbers of beneficial colonic bifidobacteria and impaired immunity. Galactooligosaccharides (GOSs) stimulate the growth of bifidobacteria in younger adults, but little is known about their effects in the elderly and their immunomodulatory capacity.

Objective: We assessed the effect of a prebiotic GOS mixture (B-GOS) on immune function and faecal microflora composition in healthy elderly subjects.

Design: In a double-blind, placebo-controlled, crossover study, 44 elderly subjects were randomly assigned to receive either a placebo or the B-GOS treatment (5.5g/d). Subjects consumed the treatments for 10 weeks, and then went through a 4 week washout period, before switching to the other treatment for the final 10 weeks.

Blood and faecal samples were collected at the beginning, middle (5 weeks), and end of the test period.
Predominant bacterial groups were quantified, and phagocytocis, natural killer (NK) cell activity, cytokine production, plasma cholesterol, and HDL cholesterol were measured.

Results: B-GOS significantly increased the numbers of beneficial bacteria, especially bifidobacteria, at the expense of less beneficial groups compared with baseline and placebo. Significant increase in phagocytosis, NK cell activity, and the production of anti-inflammatory cytokine interleukin-10 (IL-10) and significant reduction in the production of pro-inflammatory cytokines (IL-6, IL-1β, and tumour necrosis factor-α) were observed. B-GOS exerted no effects on total cholesterol or HDL-cholesterol production, however.

Conclusions: B-GOS administration to healthy elderly persons resulted in positive effects on both the microflora composition and the immune response. Therefore, B-GOS may be a useful dietary candidate for the enhancement of gastro-intestinal health and immune function in elderly persons.


Vulevic J et al. Am J Clin Nutr 2008;88:1438-46.




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