Scientific Studies

Unlike many other food supplements, Bimuno® is underpinned by a large and growing body of published scientific evidence.


A mixture containing galactooligosaccharide (B-GOS), produced by the enzymatic activity of Bifidobacterium bifidum, reduces Salmonella enterica serovar Typhimurium infection in mice


Background: The prebiotic Bimuno® is a mixture containing galacto-oligosaccharide, produced by the galactosyltransferase activity of Bifidobacterium bifidum NCIMB 41171i in the presence of lactose. Previous studies have implicated prebiotics in reducing infections by enteric pathogens, testing the hypothesis that Bimuno® may confer some protection in the murine host from Salmonella enterica serovar Typhimurium (S. Typhimurium) infection.

Design: In this study, infection caused by S. Typhimurium SL 1344nal in the presence or absence of Bimuno® was assessed using tissue culture assays, a murine ligated ileal gut loop model and a murine oral challenge model.

Results: In tissue culture adherence and invasion assays with HT-29-16E cells, the presence of ~2mM Bimuno® significantly reduced the invasion of S. Typhimurium SL 1344nal (P<0.0001). In the murine ligated ileal gut loops, the presence of Bimuno® prevented colonization and the associated pathology of S. Typhimurium. IIn the BALB/c mouse model, the oral delivery of Bimuno® prior to challenge with S. Typhimurium resulted in significant reductions in colonization in the five organs sampled, with highly significant reductions being observed in the spleen at 72 and 96 h post-challenge (P=0.0002, P<0.0001, respectively).

Conclusion: Collectively, the results indicate that Bimuno® significantly reduced the colonization and pathology associated with S. Typhimurium infection in a murine model system, possibly by reducing the invasion of the pathogen into host cells.


Searle LEJ et al. Journal of Medical Microbiology 2009;58:37-48





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