Mixture of B-GOS reduces markers of Metabolic Syndrome in overweight adults

A mixture of trans-Galactooligosaccharides reduces markers of Metabolic Syndrome and modulates the fecal microbiota and immune function of overweight adults

Background: The gut microbiota is altered towards a less beneficial composition in overweight individuals which may be linked to an increased risk of metabolic syndrome, a set of disorders that increases the risk of developing cardiovascular disease, type 2 diabetes and cancer.

Aim: To investigate the efficacy of trans-galactooligosaccharide (B-GOS®) in altering the colonic microflora of overweight individuals and its impact on risk factors of metabolic syndrome.

Methods: 44 overweight adults with >3 risk factors associated with metabolic syndrome completed a 12-week double blind placebo controlled clinical crossover trial. Patients were randomized to receive either 5.5g prebiotic, or 5.5g/d placebo.

Fecal samples were taken prior to, during and at the end of the trial for bacterial analysis as well as whole blood for C-reactive protein, insulin, and full blood count and immunological analysis. BP, BMI and waist circumference were also recorded.

Results: B-GOS increased the number of fecal bacteria at the expense of less desirable groups. Increases in fecal secretory IgA and decreases in fecal calprotectin, plasma C-reactive protein, insulin, total cholesterol (TC), triglycerides (TG) and the TC:HDL cholesterol ratio were also observed.

Conclusion: Administration of B-GOS to overweight adults resulted in positive effects on the composition of the gut microbiota, the immune response and insulin, TC and TG concentrations. B-GOS may be a useful candidate for the enhancement of gastrointestinal health, immune function, and the reduction of metabolic syndrome risk factors in overweight adults.

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Vulevic J et al. J. Nutr.2013;143:324-331


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