Scientific Studies

Unlike many other food supplements, Bimuno® is underpinned by a large and growing body of published scientific evidence.


A novel Galacto-Oligosaccharide mixture (B-GOS) increases the Bifidobacterial population in a continuous in vitro fermentation system and in the proximal colonic contents of pigs in-vivo.


Background: Prebiotics are non-digestible food ingredients that encourage proliferation of selected groups of the colonic microflora, thereby altering the composition towards a more beneficial community.

Design: In the present study, the prebiotic potential of a novel galacto-oligosaccharide GOS (B-GOS) mixture, produced by the activity of galactosyltransferases from Bifidobacterium bifidum 41171 on lactose, was assessed in-vitro and in a parallel continuous randomised pig trial.

In situ fluorescent hybridization with 16S rRNA-targeted probes was used to investigate changes in total bacteria, Bifidobacteria, lactobacilli, bacteroides, and Clostridium histolyticum group in response to supplementing the novel GOS (B-GOS) mixture.

Results: In a three stage continuous culture system, the Bifidobacterial numbers for the first 2 vessels, which represented the proximal and traverse colon, increased (P<0.05) after the addition of the oligosaccharide mixture. In addition, then oligosaccharide mixture strongly inhibited the attachment of enterohepatic Escherichia coli (P<0.01) and Salmonella enterica serotype Typhimurium (P<0.01) to HT29 cells.

Conclusion: Addition of the novel mixture at 4% (wt:wt) to a commercial diet increased the density of Bifidobacteria (P<0.001) and the acetate concentration (P<0.001), and decreased the pH (P<0.001) compared with the control diet and the control diet supplement with inulin, suggesting a great prebiotic potential for the novel oligosaccharide mixture.


Tzortzis et al. J Nutr 2005;135:1726-1731




Back to Scientific Studies


This section is an information and educational resource for healthcare professionals, scientists, researchers and journalists. It is not intended for consumers. If you wish to purchase Bimuno please click here

Back to the top