Scientific Studies

Unlike many other food supplements, Bimuno® is underpinned by a large and growing body of published scientific evidence.

 

A novel Galacto-Oligosaccharide mixture (B-GOS) increases the Bifidobacterial population in a continuous in vitro fermentation system and in the proximal colonic contents of pigs in-vivo.

 

Background: Prebiotics are non-digestible food ingredients that encourage proliferation of selected groups of the colonic microflora, thereby altering the composition towards a more beneficial community.

Design: In the present study, the prebiotic potential of a novel galacto-oligosaccharide GOS (B-GOS) mixture, produced by the activity of galactosyltransferases from Bifidobacterium bifidum 41171 on lactose, was assessed in-vitro and in a parallel continuous randomised pig trial.

In situ fluorescent hybridization with 16S rRNA-targeted probes was used to investigate changes in total bacteria, Bifidobacteria, lactobacilli, bacteroides, and Clostridium histolyticum group in response to supplementing the novel GOS (B-GOS) mixture.

Results: In a three stage continuous culture system, the Bifidobacterial numbers for the first 2 vessels, which represented the proximal and traverse colon, increased (P<0.05) after the addition of the oligosaccharide mixture. In addition, then oligosaccharide mixture strongly inhibited the attachment of enterohepatic Escherichia coli (P<0.01) and Salmonella enterica serotype Typhimurium (P<0.01) to HT29 cells.

Conclusion: Addition of the novel mixture at 4% (wt:wt) to a commercial diet increased the density of Bifidobacteria (P<0.001) and the acetate concentration (P<0.001), and decreased the pH (P<0.001) compared with the control diet and the control diet supplement with inulin, suggesting a great prebiotic potential for the novel oligosaccharide mixture.

 

Tzortzis et al. J Nutr 2005;135:1726-1731

 

 

 

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